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@AnxietyAnnie !
more questions:
Section 2, item 39/50
36yo woman comes to the physician because of a 2 week history of fatigue, bleeding of the gums, and bone pain. Physical examination shows pallor, hepatoesplenomegaly, and ecchymotic lesions over the extremities. Labs:
Hb 8g/dl
Ht 25%
Leukocytes: 36,000
segm neutr 4%
eosinophils 4%
lymph 6%
mono 6%
promielo 80%
platelets 25,000
Polymerase chain reaction test shows an mRNA crresponsing to the retinoic acid receptor- alfa/promyelocytic leukemia fusion gene resulting from a reciprocal translocation of chromossomes 15 and 17. Treatment w/ all-trans retinoic acid is started. In response to the therapy, the fusion protein will most likely attract which of the following pronteins to form a pre-transcriptional complex?
a)histone acetylase
b)histone kinase
c) histone N-methyltransferase
d) nitric oxide
e) protein kinase A (incorrect)
section 1, question 13/50
25 yo mand who has a history of facial flushing and rapid heart rate each time he consumes a small amount of alcohol participates in a study of alcohol intolerance. colecular analysis shows the presence of a lysine (K487, oriental variant) for glutamate (E487, native variant) substitution in aldehyde dehydrogenase. the kinetic characteristics of the enzyme variants are shown:
Enzyme Km (NAD+)microM Kcat (min-1)
E487 37 180
K487 5600 9.5
based on these findings, which of the following is the most likely cause of this man's condition?
a) decreased catalyitic efficiency of K487
b)increased catalytic efficiency of E487
c) less rapid turnover by E487
d) more rapid turnover by K487
e)tigher binding of NAD+ to K487
f) weaker binding of NAD+ to E487 (incorrect)
Thanks!