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I have a patient with very poor health who cannot medically undergo surgery - heart failure, O2 dependent - but we are treating a bulky breast mass about 7 cm in size and grossly involved regional nodes.
ER is 90 plus percent positive, so she will be getting anti estrogens of some kind; the question is whether to give the radiation and anti hormones together or sequentially. Is there any data either way?
I believe there was a breast chemo study that showed better response rate if the antihormones were sequential instead of concurrent, they suggested that maybe chemo works better if growth/mitosis was not hormonally suppressed.
Any breast radiation data though?
ER is 90 plus percent positive, so she will be getting anti estrogens of some kind; the question is whether to give the radiation and anti hormones together or sequentially. Is there any data either way?
I believe there was a breast chemo study that showed better response rate if the antihormones were sequential instead of concurrent, they suggested that maybe chemo works better if growth/mitosis was not hormonally suppressed.
Any breast radiation data though?